原著論文


2021 年度以降の研究業績について記載しております．

それ以前につきましては，各研究者の「慶應義塾研究者情報データベース」等をご覧ください．

2025

  • Ester derivatives of Dictyostelium differentiation-inducing factors exhibit antibacterial activity, possibly via a prodrug-like function. Takahashi, K.; Kikuchi, H.; Nishimura, T.; Ishigaki, H.; Miura, Y.; Takahashi, A.;Kubohara, Y.  BMC Research Notes 2025, 18, 40.


  • Kinetics of inhibition of CYP3A4 and CYP2C19 activity by Jabara juice and identification of the responsible inhibitory components. Koinuma, K.; Noto, K.; Morita, T.; Uekusa, Y.; Kikuchi, H.; Shimoji, M.; Seki, H.; Yamazaki, H.; Guengerich, F. P.; Nakamura, K.; Yamamoto, K.; Imaoka, A.; Akiyoshi, T.; Ohtani, H. J. Pharm. Sci. 2025, 114(2), 849–856.



2024

  • Concentration of radioactive cesium in infant food (FY 2012–FY 2023). Zhang, T.; Nabeshi, H.; Kawamata, K.; Imamura, M.; Uekusa, Y.; Hachisuka, A.; Matsuda, R.; Teshima. R.; Akiyama, H.; Tsutsumi, T. Jpn. J. Food Chem. Safety 2024, 31(3), 111–115.


  • Synthesis of a Library of Terpenoid Alkaloid–like Compounds Containing Medium-sized Rings via Reconstruction of the Humulene Skeleton. Nishimura, T.; Shiga, K.; Sekiya, M.; Sugawara, A.; Yonezawa, T.; Kikuchi, H. Chem. Eur. J. 2024, 30(48), e202402082.


  • A longer-chain acylated derivative of Dictyostelium differentiation-inducing factor-1 enhances the antimalarial activity against Plasmodium parasites. Yoshida, N.; Kikuchi, H.; Hirai, M.; Balikagala, B.; Anywar, D. A.; Taka, H.; Kaga, N.; Miura, Y.; Fukuda, N.; Odongo-Aginya, E. I.; Kubohra, Y.; Mita, T. Biochem. Pharmacol. 2024, 225, 116243.


  • Isolation and Structure Elucidation of JBIR-157, a Skeletally Novel Aromatic Polyketide Produced by the Heterologous Expression of a Cryptic Gene Cluster. Nishimura, T.; Kudo, K.; Izumikawa, M.; Kozone, I.; Hashimoto, J.; Kagaya, N.; Suenaga, H.; Takeuchi, K.; Shin-ya, K. Chem. Pharm. Bull. 2024, 75(5), 475–479.


  • Isolation and Structure Determination of New Pyrhttps://www.mdpi.com/1420-3049/29/9/2143ones from Dictyostelium spp. Cellular Slime Molds Coincubated with Pseudomonas spp. Nishimura, T.; Murotani, T.; Sasaki, H.; Uekusa, Y.; Eguchi, H.; Ishigaki, H.; Takahashi, K.; Kubohara, Y.; Kikuchi, H. Molecules 2024, 29(9), 2143.


  • Anti-trypanosomal lignans isolated from Salvadoran Peperomia pseudopereskiifolia. Castillo, U. G.; Uekusa, Y.; Nishimura, T.; Kiuchi, F.; Martínez, M. L.; Menjívar, J.; Nakajima-Shimada, J.; Núñez, M.; Kikuchi, H. J. Nat. Prod. 2024, 87,1067–1074.


  • Compound–compound interaction analysis of baicalin and berberine derivatives in aqueous solution. Uekusa, Y.; Tanioka, C.; Nakamoto, K.; Tsutsumi, R.; Iida, C.; Enshu, N.; Nishimura, T.; Kiuchi, F.; Kikuchi, H. J. Nat. Med. 2024, 78, 590–598.


  • Dictyostelium differentiation-inducing factor 1 promotes glucose uptake via direct inhibition of mitochondrial malate dehydrogenase in mouse 3T2-L1 cells. Kubohara, Y.; Fukunaga, Y.; Shigenaga, A.; Kikuchi, H. Int. J. Mol. Sci. 2024, 25, 1889.


  • The inhibitory effect of DIF-3 on polyinosinic-polycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells. Araya, R.; Men, S.; Uekusa, Y.; Yu, Z.; Kikuchi, H.; Daitoku, K.; Minakawa, M.; Kawaguchi, S.; Furukawa, K.; Oshima, Y.; Imaizumi, T.; Seya, K. J. Pharmacol. Sci. 2024, 154, 157–165.



2023

  • Derivatives of Differentiation-Inducing Factor 1 Differentially Control Chemotaxis and Stalk Cell Differentiation in Dictyostelium discoideum. Kuwayama, H.; Kikuchi, H.; Kubohara, Y. Biology 2023, 12, 873.


  • Pharmacological Evidence That Dictyostelium Differentiation-Inducing Factor 1 Promotes Glucose Uptake Partly via an Increase in Intracellular cAMP Content in Mouse 3T3-L1 Cells. Kubohara, Y.; Fukunaga, Y.; Kikuchi, H.; Kuwayama H. Molecules 2023, 28, 7926.



2022

  • Elucidation of the inhibitory effect of (+)-hopeaphenol on polyinosinic-polycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells. Xu, L.; Yu, Z.; Uekusa, Y.; Kawaguchi, S.; Kikuchi, H.; Daitoku, K.; Minagawa, M.; Motomura, S.; Furukawa, K.; Oshima, Y.; Seya, K., Imaizumi, T. J. Pharmacol. Sci. 2022, 149, 147–157.



  • Anti-trypanosome screening of Salvadoran flora. Castillo, U. G.; Komatsu, A.; Martínez, M. L.; Menjívar, J.; Núñez, M. J.; Uekusa, Y.; Narukawa, Y.; Kiuchi, F.; Nakajima-Shimada, J. J. Nat. Med. 2022, 76, 259–267.



2021

  • A Phenylfurocoumarin Derivative Reverses ABCG2-Mediated Multidrug Resistance In Vitro and In Vivo. Kokubo, S.; Ohnuma, S.; Murakami, M.; Kikuchi, H.; Funayama, S.; Suzuki, H.; Kajiwara, T.; Yamamura, A.; Karasawa, H.; Sugisawa, N.; Ohsawa, K.; Kano, K.; Aoki, J.; Doi, T.; Naitoh, T.; Ambudkar, S. V.; Unno, M. Int. J. Mol. Sci. 2021, 22, 12502.


  • Derivatives of Dictyostelium differentiation-inducing factors suppress the growth of Plasmodium parasites in vitro and in vivo. Mita, T.; Hirai, M.; Maki, Y.; Nahar, S.; Yoshida, N.; Oshima, Y.; Kikuchi, H.; Kubohara, Y. Biochem. Pharmacol. 2021, 194, 114834.


  • Mg, K-containing microparticle: A possible active principle of a culture extract produced by a microbial consortium. Higashinakagawa, T.; Kikuchi, H.; Kuwayama, H. PLOS ONE 2021, 16, e0259297.


  • Development of Indole Alkaloid-Type Dual Immune Checkpoint Inhibitors against CTLA-4 and PD-L1 Based on Diversity-Enhanced Extracts. Suzuki, Y.; Ichinohe, K.; Sugawara, A.; Kida, S.; Murase, S.; Zhang, J.; Yamada, O.; Hattori, T.; Oshima, Y.; Kikuchi, H. Front. Chem. 2021, 766107.


  • Inhibition of Plasmodium falciparum Lysyl‐tRNA synthetase via a piperidine‐ring scaffold inspired Cladosporin analogues. Babbar, P.; Sato, M.; Manickam, Y.; Mishra, S.; Harlos, K.; Gupta, S.; Parvez, S.; Kikuchi, H.; Sharma, A. ChemBioChem 2021, 22(14), 2468–2477.


  • Dictyostelium Differentiation-Inducing Factor-1 Promotes Glucose Uptake, at Least in Part, via an AMPK-Dependent Pathway in Mouse 3T3-L1 Cells. Kubohara, Y.; Homma, Y.; Shibata, H.; Oshima, Y.; Kikuchi, H. Int. J. Mol. Sci. 2021, 22, 2293.


  • Solubility enhancement of berberine–baicalin complex by the constituents of Gardenia Fruit. Okoshi, K.; Uekusa, Y.; Narukawa, Y.; Kiuchi, F. J. Nat. Med. 2021, 75, 76–83.


  • Natural products with potential to treat RNA virus pathogens including SARS-CoV-2. Christy, M. P.; Uekusa, Y.; Gerwick, L.: Gerwick W. H. J. Nat. Prod. 2021, 84, 161–182.